Haploidentical bone marrow transplant

What is Haploidentical bone marrow transplant?

A haploidentical bone marrow transplant is performed when the donor exactly matches half of the recipient’s DNA. Haploidentical bone marrow transplant is a type of allogeneic transplant. In an allogeneic transplant, the cells from donors are transplanted in the recipient to suppress the disease-causing cells or elements and restore the immune system of the patient. The key to a successful allogeneic transplant is finding the right donor. In most cases, the donors are the blood relatives of the patient. The match is proved through tissue typing. Human Leukocyte Antigens (HLA)  are the proteins that are used for tissue typing. These proteins are present in white blood cells and tissues. HLA is present almost all over the body. Donors closely matching your HLA or umbilical cord blood can be transplanted. Healthy, blood-forming cells from a half-matched donor are transplanted to replace the unhealthy ones of the recipient. This is a Haploidentical bone marrow transplant. The donor is typically a family member in Haploidentical bone marrow transplant.  The donor matches exactly half of the HLA of the donor. 

Who can be a haploidentical donor?

The patient’s mother, father, or offspring are half-matched or haploidentical donors. Siblings have a 50% chance of being haploidentical for each other. Parents are always haploidentical to their children. It is highly unlikely for uncles, aunts, and cousins to be half-match of the patient. 

Benefits of a haploidentical bone marrow transplant

For patients suffering from rare disorders, haploidentical stem cell transplants are a blessing. It is a boon especially for patients suffering from blood disorders that do not have any cure yet. Since this medical procedure does not need a complete HLA match of the donor’s tissue, it is a treatment option for 70% of the patients suffering from rare and complex disorders. Haploidentical bone marrow transplant gives a chance to live for the patients who do not have an HLA-identical sibling donor. 

A half-match donor saves a lot of hassle for the family and doctors. It avoids the need to find an alternative donor who is unrelated to the patient. It also expands the donor pool who are not a complete match for the receiver. 

In a bone marrow transplant, the patient’s immune system is wiped out so that the immune system does not reject the donated marrow. It is done to avoid the host -versus- graft effect as the response of the donor immune system can harm the new immune system during the marrow transplant. In haploidentical bone marrow transplant, the bone marrow suppresses the immune system instead of wiping it out. It is viable to perform this procedure on children with benign hematologic disorders if no donors are available with engraftment rates of 70%, durable graft in 67%. The overall survival of haploidentical bone marrow transplant is 60%.

It is generally assumed that the side-effects of a haploidentical transplant are higher than a full-matched transplant if the procedure is performed in a busy institute. In Hematology and BMT Institute International every procedure is performed with precision and patients are given utmost care. Dr. S.K Gupta, the founder of Hematology and BMT Institute International has 15 years of experience and is an expert in Haploidentical bone marrow transplant. He started his medical career as a nursing student and has been trained at various reputed & prestigious healthcare Institutions in India.

If you are looking for a medical institute that provides quality healthcare with utmost dedication and care, head to Hematology and BMT Institute International in Hyderabad. It is one of the most advanced and efficient healthcare centers in India. 

 

Bone Marrow and Bone Marrow Transplantation

BONE MARROW AND BONE MARROW TRANSPLANTATION

Bone marrow is the thick, spongy tissue within the bones that develops red and white blood cells and platelets. As bones are present everywhere in the body so bone marrow will also be present in all parts of the body. Unspecialized Hematopoietic Stem Cells are also present in the bone marrow. These stem cells or mother cells have two properties – 

  1. Differentiation into different blood cells or daughter cells, and 
  2. Renewal into new stem cells or mother cells.

Many cancers may hinder the average production/ renewal and differentiation of such stem cells.

The bone marrow transplant is essential if the bone marrow is not healthy enough or cannot work properly due to hematological disorders or blood cancer. Bone Marrow Transplantation (BMT) is done to replace weak bone marrow with healthy bone marrow. Unlike solid organs (kidney, liver, heart) transplant, this is not a surgical process as the majority of us know/ understand. This is purely a medical procedure in which transplantation of new blood-forming hematopoietic stem cells replaces the existing weak bone marrow hematopoietic stem cells. As a result, new blood cells will be formed and will ultimately contribute to new marrow development that will cure and prevent other disorders. For bone marrow transplantation, healthy stem cells can either be extracted from the patient’s own body (autologous BMT) or from an HLA matched family or unrelated donor (allogeneic BMT). Frankly, if we speak autologous BMT is not at all a BMT as here we are using patients own hematopoietic stem cells. In autologous BMT use of the patient’s own stem cells is done to rescue him from the side effects of high-dose chemotherapy.

Dr. S.K. Gupta is a renowned Hematologist in India, practicing as a hematology consultant at Hematology and BMT Institute International with extensive experience of over 15 years in the field. He has performed over 250 Bone Marrow Transplants for patients suffering from various Hematological blood disorders in India and across the globe. He is a specialist in the treatment of all blood, bone marrow, lymph nodes, and spleen disorders. He and his team are comfortable in treating children’s also. Let’s look at some interesting points that he came across while treating one of his patients.

In 2015, a girl was diagnosed with blood cancer and had relapsed three times.  A curative therapy was used through Allogeneic Bone Marrow Transplantation as it was the mother who donated the stem cells which was only half matching  (Haploidentical )and they did not have a fully matched HLA (Human Leukocyte Antigens) donor. Due to this reason, all the other oncologists were reluctant to go on with the procedure because Allogeneic BMT/HSCT is more complicated and demanding than Autologous BMT/HSCT. This is a recent and much-needed advancement in the field of HSCT since the first successful HSCT was done 40 years ago (1968). It was even more challenging to conduct regular services due to COVID-19, especially when the hospital is treating active COVID-19 patients. Dr. S.K. Gupta not only provides excellent treatment but also patiently answers all the queries related to the illness. He motivates and urges people not to give up. 

 

There are few myths about BMT which need to be busted:

 

Patient perspective:-

  •  It is a Surgical Procedure.
  •  Surgery is the last resort in treatment, we should try some medicines and if they don’t work only then should we go with this treatment.
  • A matching blood group is a must.
  • I will receive lifelong treatment.
  • It’s a very high-risk procedure

Donor perspective:-

  • The donor will have a lot of side effects, the blood-producing capacity will go down, immunity will go down, the capacity to fight COVID19 will go down, etc.
  • Umbilical cord Hematopoietic Stem Cells are stored for the child, so there is no need to worry.

Hematology and BMT Institute International is a global healthcare hospital that provides quality care to the people. We provide guidance and treatment as per recent developments across the world. We follow strict protocols when using the equipment and while handling patients by keeping in mind the sensitive nature of the patient’s medical conditions.

Visit our website https://hematologybmt.com/ or contact us on +917780297660 to know more about hematology and the kind of treatments that Dr. Gupta provides to his patients. 

 

 

 

 

 

Bone Marrow Transplant Cost in Hyderabad

Bone Marrow Transplant Cost in Hyderabad

Bone Marrow Transplant Cost in Hyderabad is less than one-tenth of the price as compared to many other developed countries. The Bone Marrow Transplant Cost in Hyderabad is in the range of 28K to 40K USD in some of the Best Hospitals in Hyderabad for bone marrow transplant.

Here are some Country, and their cost of Bone marrow transplant in dollar and INR 

UNITED KINGDOM

$4,00,000 (INR 2,52,00,000)

USA 

$5,00,500 (INR 3,15,00,000)

FRANCE

$3,50,000 (INR 2,20,00,000)

GERMANY

$2,25,000 (INR 1,41,75,000) 

TURKEY

$1,00,000 (INR 63,50,000) 

Source : Google Thank you 

Bone Marrow Transplant Cost in Hyderabad

This includes the cost of the procedure, operation theatre, routine standard medicines, anesthesia, bedside procedures, surgeon’s fees, food and room charges for the patient etc.

Bone marrow transplant is a procedure to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Bone marrow is the soft, fatty tissue inside your bones. The bone marrow produces blood cells. Stem cells are immature cells in the bone marrow that give rise to all of your different blood cells.

Bone Marrow Transplant Cost in Hyderabad

Bone Marrow Transplant is also called a stem cell transplant, Bone Marrow Transplant is used to treat some types of cancers. 

Our experienced and dedicated multidisciplinary doctors are providing Best Bone Marrow Transplantation in Hyderabad, India.

Best Hematologist in Kukatpally

Spleen Specialist in Hyderabad

Splenectomy could be a surgical treatment during which the spleen is far from the body of the patient. This procedure is usually performed for patients that have enlarged spleens, busted spleens, or sure cancers. In laparoscopic cutting out, the medico makes little incisions within the abdomen to guide little cameras, instruments, and devices into the body so as to look at and treat the spleen.

Spleen Specialist in Hyderabad

Spleen Specialist in Hyderabad

 

Dr. S.K. Gupta is one of the Best Spleen Specialist in Hyderabad. He is a renowned Hematologist in India with extensive experience of over 15 years in the field of Hematology.

The medico will then perform the removal during a minimally-invasive manner. In some cases, like that of the busted spleen, the doctor may perform open surgery, and build an oversized incision within the abdominal space to directly access the spleen. In partial cutting out, solely a part of the spleen is removed.

Splenectomy could be an operation during which the spleen is off from the body of the patient. This procedure is mostly performed for patients that have enlarged spleens, burst spleens, or bound cancers. In laparoscopic cutting out, the operating surgeon makes tiny incisions within the abdomen to guide tiny cameras, instruments, and devices into the body so as to look at and treat the spleen. 

The operating surgeon will then perform the removal in a minimally-invasive manner. In some cases, like that of the burst spleen, the doctor would possibly perform open surgery and build an outsized incision within the abdominal space to directly access the spleen. In partial cutting out, solely a part of the spleen is removed.

Spleen Specialist in Hyderabad

Spleen Specialist in Hyderabad

Symptoms

  • No symptoms in some cases
  • Pain or fullness in the left upper abdomen that may spread to the left shoulder
  • Easy bleeding
  • Anemia
  • Feeling full without eating or after eating only a small amount from the enlarged spleen pressing on your stomach
  • Fatigue
  • Frequent infections

Risk factors

Spleen at any age, but certain groups are at higher risk, including:

  • People who have Gaucher’s disease, Niemann-Pick disease, and several other inherited metabolic disorders affecting the liver and spleen.
  • Children and young adults with infections, such as mononucleosis.
  • People who live in or travel to areas where malaria is common.
Pancytopenia specialist in Hyderabad

Pancytopenia Specialist in Hyderabad

Dr. S.K. Gupta is one of the Best Pancytopenia Specialists in Hyderabad. He is a renowned Hematologist in India with extensive experience of over 15 years in the field of Hematology. Moreover, proper monitoring of the patient’s condition, boosting the morale of both patient as well family are also key steps in reducing the morbidity and mortality during the treatment which Dr. S.K. Gupta takes care at a personal level along with his strong supportive team. At the same time, he is running a lot of awareness camps at the community level for the same to benefit all age groups of patients ranging from new-born to elderly.

What is Pancytopenia?

Pancytopenia refers to the combination of anemia, leukopenia, and thrombocytopenia. Causes may be due to bone marrow failure, bone marrow infiltration, ineffective hematopoiesis or peripheral pooling/destruction. A bone marrow aspirate is usually required to establish the diagnosis. Aetiologies of pancytopenia vary from one geographical region to others.

Various etiological factors have been implicated in the causation of pancytopenia. Major factors include a reduction in blood cell production, infiltration of bone marrow (BM) by abnormal cells, suppression of BM, ineffective hematopoiesis with cell destruction, antibody-mediated destruction of cells, and sequestration of cells in the reticuloendothelial system. Treatment and prognosis of patients with pancytopenia are governed by the cause and severity of the underlying disease.

Pancytopenia specialist in Hyderabad

Pancytopenia is caused by various conditions. There are various predisposing factors for these anemias like alcoholism, hypothyroidism, self-limiting illnesses, puberty, pregnancy.

Therefore it is necessary to treat such cases with iron and/or vitamin B12/folate, to repeat hemogram after a few weeks and if necessary further evaluation with an invasive procedure like bone marrow may be considered.

There are other treatable causes like dengue, malaria, enteric fever, and TB. In such cases, pancytopenia resolves over sometime after etiology specific treatment is given. However, the bone marrow becomes necessary if there is no improvement or there are signs which are suggestive of severe diseases like leukemia, MDS, etc.

For More Information visit: HEMATOLOGY & BMT INSTITUTE INTERNATIONAL

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