Haploidentical bone marrow transplant

What is Haploidentical bone marrow transplant?

A haploidentical bone marrow transplant is performed when the donor exactly matches half of the recipient’s DNA. Haploidentical bone marrow transplant is a type of allogeneic transplant. In an allogeneic transplant, the cells from donors are transplanted in the recipient to suppress the disease-causing cells or elements and restore the immune system of the patient. The key to a successful allogeneic transplant is finding the right donor. In most cases, the donors are the blood relatives of the patient. The match is proved through tissue typing. Human Leukocyte Antigens (HLA)  are the proteins that are used for tissue typing. These proteins are present in white blood cells and tissues. HLA is present almost all over the body. Donors closely matching your HLA or umbilical cord blood can be transplanted. Healthy, blood-forming cells from a half-matched donor are transplanted to replace the unhealthy ones of the recipient. This is a Haploidentical bone marrow transplant. The donor is typically a family member in Haploidentical bone marrow transplant.  The donor matches exactly half of the HLA of the donor. 

Who can be a haploidentical donor?

The patient’s mother, father, or offspring are half-matched or haploidentical donors. Siblings have a 50% chance of being haploidentical for each other. Parents are always haploidentical to their children. It is highly unlikely for uncles, aunts, and cousins to be half-match of the patient. 

Benefits of a haploidentical bone marrow transplant

For patients suffering from rare disorders, haploidentical stem cell transplants are a blessing. It is a boon especially for patients suffering from blood disorders that do not have any cure yet. Since this medical procedure does not need a complete HLA match of the donor’s tissue, it is a treatment option for 70% of the patients suffering from rare and complex disorders. Haploidentical bone marrow transplant gives a chance to live for the patients who do not have an HLA-identical sibling donor. 

A half-match donor saves a lot of hassle for the family and doctors. It avoids the need to find an alternative donor who is unrelated to the patient. It also expands the donor pool who are not a complete match for the receiver. 

In a bone marrow transplant, the patient’s immune system is wiped out so that the immune system does not reject the donated marrow. It is done to avoid the host -versus- graft effect as the response of the donor immune system can harm the new immune system during the marrow transplant. In haploidentical bone marrow transplant, the bone marrow suppresses the immune system instead of wiping it out. It is viable to perform this procedure on children with benign hematologic disorders if no donors are available with engraftment rates of 70%, durable graft in 67%. The overall survival of haploidentical bone marrow transplant is 60%.

It is generally assumed that the side-effects of a haploidentical transplant are higher than a full-matched transplant if the procedure is performed in a busy institute. In Hematology and BMT Institute International every procedure is performed with precision and patients are given utmost care. Dr. S.K Gupta, the founder of Hematology and BMT Institute International has 15 years of experience and is an expert in Haploidentical bone marrow transplant. He started his medical career as a nursing student and has been trained at various reputed & prestigious healthcare Institutions in India.

If you are looking for a medical institute that provides quality healthcare with utmost dedication and care, head to Hematology and BMT Institute International in Hyderabad. It is one of the most advanced and efficient healthcare centers in India. 




Desmond Tutu once said, “Hope is being able to see that there is light despite all of the darkness.” It all started in December 2019, when Komal’s (name changed) mother, Aruna (name changed) fell sick after attending a marriage in their village.
After medical consultation, small reddish
spots were observed on her skin, which initially appeared to be normal mosquito bites. After a couple of days, Komal took her mother, Aruna to a clinic for her regular diabetic checkup, where she also mentioned the red spots to the doctor. The doctor suggested taking a CBP test (Complete Blood Count), which showed low platelets count. The doctor advised an immediate admission to the hospital as the platelet count was below 1 lakh, and other tests revealed that she was also dengue positive. 

Aruna’s treatment went on for 10 days with no sign of improvement. Despite the proper medication, her platelet count went down to 30,000. When the family discussed with the doctor, he advised consulting a specialized Hematologist in a corporate hospital in Hyderabad. 

Upon meeting the Hematologist at the hospital, the doctor advised going for a Complete Hemogram Count(CBC) and ANA by IF test, an Antinuclear antibody test by Immunofluorescence method. By the time the family received the report,  the platelet count went down to  10,000, and ANA by IF test results were negative. The Doctor informed them that it’s not dengue, but a disease called ITP (Immune Thrombocytopenia), in which platelets get destroyed by one’s own body cells. Aruna was admitted due to the low platelet count and immediately one SDP (Single Donor Platelets) was transmitted. Her platelet count rose above 1 lakh and she was discharged the next day but the doctor advised her to stay on medication, and she was kept under steroids (Omni Cortile & Romiplostim) for a month. Despite the regular medication, Aruna’s health was not improving,  platelets were about 20,000 on and off, so 6 packets of SDP were transmitted again. As there was no development in her condition, the doctor advised further tests; a Bone Marrow Biopsy to check the functionality of the bone marrow.

Only after the tests did the family found out that Aruna was suffering from Severe Aplastic Anemia. In such conditions, the bone marrow does not make enough blood cells for the body to function smoothly. 

A doctor suggested taking an appointment with Dr.S.K.Gupta in Hematology BMT Institute International. He is one of the best hematologists in India and a specialist in treating blood disorders, bone marrow, lymph nodes, and spleen disorders.
Dr.S.K.Gupta studied the reports and explained that the patient did not suffer from ITP, but confirmed that she had Severe Aplastic Anemia. The doctor patiently elucidated the entire situation to the family, which helped them to get a better understanding of the disorder. 

On 16th Feb 2020, the patient was admitted to Hematology BMT Institute International under the supervision of Dr. S.K.Gupta. On the first day, CBP test reports showed that the platelets were very low,  so the doctor advised to have an SDP transfusion and other initial baseline procedure tests like CT, MRI, abdominal ultrasound test. Aruna was discharged for a few days until the final reports were examined by Dr. Gupta.

Aruna was admitted to the hospital after a week and the treatment procedure was immediately taken over by Dr. Gupta and his team. Dr.S.K. Gupta visited her every day to check her health. Along with the treatment, Dr.Gupta also arranged counseling sessions every week to clear doubts regarding the treatment. 

During Aruna’s treatment for the last 6 months, she received only a single RDP (Random Donor Platelets) and RBC (Red Blood Cells) through transfusion. 

Dr.S.K.Gupta was also very patient in answering the questions and did not hesitate to respond to doubts and queries of the patient and family. Komal commented, “I strongly recommend Dr.S.K.Gupta not because he treated my mother but, because his knowledge and passion towards treating his patients are impeccable.” 

Dr.S.K.Gupta is one of the best hemato-oncologist doctors in Hyderabad. With over 15 years of experience, he’s an expert in treating blood disorders like Leukemia, Lymphoma, Multiple Myeloma, Aplastic Anemia, Thalassemia and Sickle Cell disease, Hemophagocytic syndromes, Immunodeficiencies, and spleen disorders. Dr.Gupta says that proper monitoring of the patient’s condition and boosting the morale of both the patient and the family are the key steps in reducing morbidity and mortality during the treatment. 

The Hematology and BMT Institute International in Hyderabad is the best in treating any blood-related disorders.
If you want to book an appointment or want to connect with Dr.Gupta, then visit
https://hematologybmt.com/ or contact at 7780297660. 



A diagnosis of blood cancer can change lives; not only for the patients but also for their family and friends who love them. Let’s look at Bhavya’s (name changed) cancer treatment journey and experience with Dr. S.K. Gupta at Hematology BMT Institute International

Bhavya was 6 years old when she was diagnosed with blood cancer. It all started in mid-January 2019 when she started suffering from fever, cough, and cold. She also started losing weight drastically. Her family took her to a local hospital at Shadnagar but no difference was seen in her health. As time passed by, the fever started rising along with tremendous weight loss and mouth ulcers. The Government Hospital at Shadnagar conducted various tests and asked her family to take her to any good hospital. Later, Bhavya’s family took her to their native place located in Solapur, Maharashtra.

In March 2019, she was admitted to Markandeya Sahakari Rugnalaya under the observation of Dr. Shrishi Keyur. Treatments started and several tests were performed. The doctor after studying the results told Bhavya’s uncle that Bhavya is diagnosed with cancer. Her family tried consulting various other doctors but none of them matched their expectations. Finally, Bhavya’s uncle, Anand (name changed) insisted on consulting a Paediatric Hematologist, Dr. Dhinanth Mangeshkar in Pune.  The doctor informed the family that Bhavya is suffering from blood cancer and it has already spread across 95% of her body. The doctor insisted on starting the treatment immediately.

Amidst the dilemma, Bhavya’s family came to know about Dr. S.K. Gupta, senior consultant and founder at Hematology BMT Institute International, Hyderabad. Upon reaching the hospital, Prema, Dr. Gupta’s assistant, received them and took a brief medical history of Bhavya. Dr. Gupta guided Bhavya and her family through blood cancer and its treatments. Her family felt relaxed after receiving the doctor’s counseling. Bone marrow, Fisher mark, and other tests were done to understand what exactly is the case. Dr. Gupta then started Chemotherapy, which was a difficult phase for Bhavya and her family. Bhavya’s Chemotherapy lasted for 4 months. It was a difficult phase especially when the WBCs and platelet count were being closely monitored. During these times, the hospital management was so keen and supportive that it made it easier for the family to stay strong. Dr. Gupta spent time listening and answering the patient and her family member’s questions. He treated Bhavya as his child and played with her during his visits, which motivated her for a faster recovery. 

Bhavya’s mother said, “A heartfelt thanks to Dr. Gupta for my daughter’s second birth. Thanks to the management and staff for their all-time support. It was a great experience at Hematology and BMT Institute International.”

Dr. S.K. Gupta is a renowned hematologist in India with experience of over 15 years, practicing as a senior hematology consultant at Hematology BMT Institute International. He is an expert in treating blood, bone marrow, lymph nodes, and spleen disorders. Dr. S.K. Gupta strongly believes that the cornerstones of fruitful outcomes even in life-threatening hematological disorders are early diagnosis, proper guidance, and support. Adequate monitoring of the patient’s condition, improving the morale of both the patient and the family, are also crucial steps in reducing morbidity and mortality during treatment. 

At Hematology BMT Institute International, we have the best cancer doctors, who specialize in treating blood cancer with surgery, chemotherapy, bone marrow transplant, biological therapy, and hemato-oncology.


Book an appointment with Dr. S.K. Gupta, an experienced cancer specialist at Hematology BMT Institute International, one of the best cancer hospitals in India. Visit our website https://hematologybmt.com/ or call us at +91 7780297660. 




Realizing you have cancer is not a good experience but that moment when you know you won over cancer is truly a memorable one. You might feel depressed, frightened, or even exhausted following your cancer diagnosis. Blood cancer is one such type of cancer that occurs when abnormal blood cells start growing out of control, interrupting the functioning of normal blood cells. But, with the advancement of medical science in our country, untreatable cancer diseases now have different ways of treatment. An important part of coping with any type of cancer is recognizing the feelings and emotions connected to it. Understanding what the disease is all about and what treatments can be taken will help you in fighting the disease. For a blood cancer patient and their family, it is important to understand what and when a bone marrow transplant is required and its process. 

The bone marrow creates blood stem cells which may become any form of blood cell that the body requires. Stem cells differentiate and grow continuously into different kinds of blood cells, replacing old and worn-out blood cells in the body. Billions of new blood cells are formed each day. If the stem cells are unable to generate sufficient fresh blood cells, there could be other severe health issues. These health issues can include infection, bleeding, or anemia. 

A human body requires strong stem cells to lead a healthy life. These stem cells get destroyed during cancer treatments in which case we can use Stem Cell Transplantation.

Let’s look at what Stem Cell Transplantation is:

Stem Cell Transplantation (SCT) is a process in which a recipient accepts healthy stem cells to supplement damaged stem cells. It is also referred to as bone marrow transplantation. Before SCT, the patient takes heavy doses of chemotherapy and occasionally radiation therapy to allow the body for transplantation. This is “conditioning therapy.” They move to the bone marrow after the stem cells are injected into the patient’s bloodstream to initiate the cycle of producing new, healthier blood cells, including white blood cells, red blood cells, and platelets. This cycle is called ‘engraftment’.The complete stem cell transplantation procedure differs from person to person.

Some of the general procedures involved are:

  • Evaluation and pre-transplant texting
  • Identifying the type of transplantation required for the patient.

    There are 3 types of transplantation:

    a) Autologous:-
    Involves the use of the patient’s own stem cells. After a conditioning regime, these cells are extracted, processed and restored to his or her own body.
    b) Syngeneic:- This is when the stem cells are used from an identical twin.
    c) Allogeneic:– Obtaining blood stem cells from a donor

  • Conditioning treatment: The patient receives chemotherapy or radiation to kill any of the diseased cells in the body and to establish room for the transplanted stem cells to grow in the bone marrow.
  • Transplanting the new stem cells into the patient
  • Engraftment and recovery: Transplanted stem cells continue developing and reproducing healthy blood cells. Engraftment lasts approximately two to three weeks for bone marrow or blood Stem Cell Transplantation whereas, for cord blood transplantation, the procedure requires three to five weeks. At this time, most patients remain in the hospital to be shielded from infection and treated for side effects, while selected patients might be outpatients.

Dr. S.K. Gupta is a renowned Hematologist in India, with extensive experience of over 15 years in the field of Hematology. He possesses expertise in blood, bone marrow, lymph nodes, and spleen disorders. Dr.S.K. Gupta strongly believes that early diagnosis, proper guidance & support are the cornerstones of fruitful outcomes even in life-threatening hematological disorders. 

Hematology BMT Institute International is the best hospital providing treatment for all blood-related diseases. The hospital is located in Hyderabad and is a proactive solution to the critical needs of today’s healthcare industry, mainly delivering reliable and accessible medical treatment through dedicated and qualified healthcare professionals. The aim is to introduce the highest level of knowledge and abilities used in the treatment of patients with the use of modern and innovative accessible equipment to offer great treatment at reasonable prices.

If you want to know more about blood disorders and their treatment, visit the website https://hematologybmt.com/ or contact us on +917780297660.



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